Escitalopram- Antidepressant

in Drug Directory

The antidepressant action of escitalopram is presumably linked to the potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibitory effect on the reuptake of 5-HT from the synaptic cleft. Escitalopram is the S-enantiomer of the racemate citalopram and is the enantiomer to which the therapeutic activity is attributed.

Indications:-

Depressive illness,  Generalized anxiety disorder, Obsessive-compulsive disorder, Social anxiety disorder.

Side Effect:-

Most common side effects are- decreased appetite, decreased libido, insomnia, somnolence, dizziness, sinusitis, nausea, diarrhoea, constipation, sweating increased, ejaculation disorder, impotence, fatigue, pyrexia.

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Precaution:-

dysphoric mood, irritability, agitation, anxiety, confusion, sensory disturbances, insomnia, dizziness.

Contraindications:-

Escitalopram should not be used if- *The patient enters a manic phase *Hypersensitive to escitalopram and any excipients of the product *The patient is taking monoamine oxidase inhibitor (MAOI), reversible MAOI (RIMA) and moclobemide.

Use in Pregnancy & Lactation:-

Escitalopram has had limited use in pregnancy without a reported increase in birth defects. Neonates should be observed if maternal use of Escitalopram continues into the later stages of pregnancy, particularly in the third trimester.

Drug Interaction:-

CNS drugs –  caution should be used when escitalopram is taken in combination with other centrally acting drugs.
MAO Inhibitors – There have been reports of serious, sometimes fatal reactions when escitalopram is taken in combination with MAO inhibitors.

Overdose:-

Tremor, somnolence, unconsciousness, seizures, tachycardia, changes in the ECG, respiratory depression etc.

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