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Adverse Drug Reactions

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Adverse drug reactions (ADRs) are types of adverse drug events (ADEs). ADEs include ADRs, medication errors, and other drug-related problems. ADEs are the negative

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Drug Tolerance

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Tolerance may be defined as either (1) the loss of effect over time to the same dose of a drug or (2) the need for more of a drug over time to get the same effect. Tolerance, at first, appears¬†counterintuitive because addition of more of an activating ligand lessens the elicited response. [wp_ad_camp_5]¬†Recall, however, that receptor number and receptor sensitivity are dynamic and that signaling can adjust based on the conditions of ligand availability. Given that drugs often times act…

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