Escitalopram- Antidepressant

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The antidepressant action of escitalopram is presumably linked to the potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibitory effect on the reuptake of 5-HT from the synaptic cleft. Escitalopram is the S-enantiomer of the racemate citalopram and is the enantiomer to which the therapeutic activity is attributed.

Indications:-

Depressive illness,  Generalized anxiety disorder, Obsessive-compulsive disorder, Social anxiety disorder.

Side Effect:-

Most common side effects are- decreased appetite, decreased libido, insomnia, somnolence, dizziness, sinusitis, nausea, diarrhoea, constipation, sweating increased, ejaculation disorder, impotence, fatigue, pyrexia.

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Precaution:-

dysphoric mood, irritability, agitation, anxiety, confusion, sensory disturbances, insomnia, dizziness.

Contraindications:-

Escitalopram should not be used if- *The patient enters a manic phase *Hypersensitive to escitalopram and any excipients of the product *The patient is taking monoamine oxidase inhibitor (MAOI), reversible MAOI (RIMA) and moclobemide.

Use in Pregnancy & Lactation:-

Escitalopram has had limited use in pregnancy without a reported increase in birth defects. Neonates should be observed if maternal use of Escitalopram continues into the later stages of pregnancy, particularly in the third trimester.

Drug Interaction:-

CNS drugs –  caution should be used when escitalopram is taken in combination with other centrally acting drugs.
MAO Inhibitors – There have been reports of serious, sometimes fatal reactions when escitalopram is taken in combination with MAO inhibitors.

Overdose:-

Tremor, somnolence, unconsciousness, seizures, tachycardia, changes in the ECG, respiratory depression etc.

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