Casarett & Doull’s Toxicology: The Basic Science of Poisons

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Louis J. Casarett & John Doull – Toxicology : The Basic Science of Poisons

[column]The seventh edition of Casarett and Doull’s Toxicology: The Basic Science of Poisons, as the previous six, is meant to serve primarily as a text for, or an adjunct to, graduate courses in toxicology. Because the six previous editions have been widely used in courses in environmental health and related areas, an attempt has been made to maintain those characteristics that make it useful to scientists from other disciplines. This edition will again provide information on the many facets of toxicology, especially the principles, concepts, and modes of thoughts that are the foundation of the discipline. Mechanisms of toxicity are emphasized. Research toxicologists will find this book an excellent reference source to find updated material in areas of their special or peripheral interests.
The overall framework of the seventh edition is similar to the sixth edition. The seven units are “General Principles of Toxicology” (Unit 1), “Disposition of Toxicants” (Unit 2), “Non-Organ-Directed Toxicity” (carcinogenicity, mutagenicity, and teratogenicity) (Unit 3), “Target Organ Toxicity” (Unit 4), “Toxic Agents” (Unit 5), “Environmental Toxicology” (Unit 6), and “Applications of Toxicology” (Unit 7).[/column]

This edition reflects the marked progress made in toxicology during the last few years. For example, the importance of apoptosis, cytokines, growth factors, oncogenes, cell cycling, receptors, gene regulation, transcription factors, signaling pathways, transgenic animals, “knock-out” animals, polymorphisms, microarray technology, genomics, proteonomics, etc., in understanding the mechanisms of toxicity are included in this edition. More information on environmental hormones is also included. References in this edition include not only traditional journal and review articles, but, internet sites also. (Readers who would like a Power- Point version of the figures and tables can obtain the same from the publisher.)
The editor is grateful to his colleagues in academia, industry, and government who have made useful suggestions for improving this edition, both as a book and as a reference source. The editor is especially thankful to all the contributors, whose combined expertise has made possible a volume of this breadth. I especially recognize John Doull, the original editor of this book, for his continued support. [end_columns]





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